War in the Body by W David Wick & Otto O Yang

Author:W David Wick & Otto O Yang
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

9.1 When Invisibility Is a Necessity

Can we gain a theoretical understanding of the stability of Nef function in vivo? We next show that theory, combined with new estimates of enhanced CTL killing due to loss of Nef function can indeed explain the necessity of maintaining Nef. Let “CIF” stand for “CTL enhancement factor”, meaning the proportional increase in CTL killing that would accrue if HIV lost the HLA-downregulation function. As in Chapter 5, let LOF m denote the loss-of-fitness associated with a mutation in Nef that simultaneously deletes recognition of a Nef epitope and abolishes Nef action on HLA. Let “FOE” stand for “fraction of immune pressure due to other epitopes”. Then we can express the condition preventing escape in the Nef epitope (derived from the Escape Formula, see Part II, Chapter 25):

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